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How Glyphosate Infiltrates Your Brain

Glyphosate Injury lawyer, Mike Ehline

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Ultimate Guide to Understanding Glyphosate Exposure

For decades, people have known herbicides as environmental contaminants. However, only recently have consumers understood the adverse health effects pesticide exposure might have on humans.

However, only recently have consumers understood the adverse health effects pesticide exposure might have on humans. The detrimental effects glyphosate exposure will cause are now proven by science. Commercial herbicides and home-use pesticides can lead to detrimental outcomes, horrific in vitro changes, and other neurodegenerative disorders. The controversial Roundup weed killer raised concerns about an active ingredient, glyphosate, warranting the need to study the substance’s effects on human health.

Research published in 2022 by Arizona State University reported that glyphosate infiltrates the brain, suggesting potential adverse health effects for Roundup users. The research shows that glyphosate successfully crosses the blood-brain barrier and infiltrates the human brain and can even onset Alzheimer’s Disease and Dementia in a dose dependent manner. Once inside, it enhances levels of a critical factor known as TNF-α. TNF-α TNF-α, which means tumor necrosis factor-alpha. When it does, we can help the victims. Ehline Law and our personal injury attorneys advocate for injured victims suffering from exposure to toxic substances, including Agent Orange, glyphosate-based herbicides, and other broad-spectrum herbicide problems like cell biology division in brain tissues.

We have recovered more than $150 million in compensation and helped over 3,000 injured victims. If you’re experiencing health problems following the use of herbicides, including Agent Orange, contact us to learn more about your brain tissue post exposure rights.

Glyphosate and Its Link to Non-Hodgkin’s Lymphoma

The glyphosate herbicide use became popular in the early 2000s, becoming Monsanto’s best-selling product. Eyeing the opportunity, Bayer acquired Monsanto for $63 billion.

When Bayer purchased Monsanto in 2018, it also acquired a hoard of legal problems Monsanto was facing. Soon, thousands of lawsuits from citizens complaining about health problems with correlations leading glyphosate-based herbicide use. The cell death in cortical neuron lawsuits all made their way to Bayer.

In 2015, the World Health Organization (WHO) identified glyphosate as a carcinogen. It warned consumers about the potential toxic effects and health risks of exposure, such as brain and spinal cord damage, non-Hodgkin’s lymphoma and other cancers.

Before the 2015 WHO warning, many studies conducted in the past, including the “A case-control study of non-Hodgkin lymphoma and exposure to pesticides” completed in 1999, suggested a link between glyphosate exposure and non-Hodgkin’s lymphoma. A 2013 research suggests that glyphosate induces human breast cancer cell growth through estrogen receptors.

Findings of Previous Studies Show Glyphosate Cross the Blood Brain Barrier

Previous studies, such as the 2011 “Aseptic meningitis in association with glyphosate-surfactant herbicide poisoning” and many more, have shown that once in the environment and you become exposed, glyphosate crosses the blood-brain barrier and leads to cell death in vitro models. However, it did not study glyphosate in human brain models, or those pathology effects extensively. Findings from previous research also suggest that exposure to herbicides for six weeks in adult rats leads to peripheral blood inflammation.

It also revealed that glyphosate exposure resulted in a detectable tumor necrosis factor-alpha (TNFα) in the examined sample rat’s liver. A 2010 research suggests that a healthy brain’s TNFα levels are pretty low. However, those suffering from cancer, psoriasis, inflammatory, and neurodegenerative diseases have shown increased levels of TNFα molecule in their brains. There is a strong link between TNFα and the progression of Alzheimer’s disease.

A 2017 research study on chronic exposure to glyphosate in mice revealed changes in brain-related function but did not establish whether the substance infiltrated the brain, inducing cell death. But things they are a changing.

Recent Experiments Suggest Effects of Glyphosate on Brain Tissue

A 2022 study explores the connection between glyphosate and neurodegenerative disorders by experimenting on 48 four-month-old mice. The mice received various doses of glyphosate per day for 14 days to study the effects of the substance. On the final day, the researchers collected urine, plasma, and brain samples to analyze for any anomalies. Let’s examine the experiment’s results and determine how glyphosate infiltrates your brain.

Glyphosate Detected in Brain Tissue

In the mice, the experiment revealed that an increased dose of glyphosate led to increased glyphosate levels in the brain. There were also higher levels of aminomethylphosphonic acid (AMPA), glyphosate’s major metabolite.

The study also found a strong correlation between brain glyphosate and AMPA; as the brain glyphosate increased, so did the levels of AMPA. It also showed a significant correlation between brain glyphosate and urine glyphosate levels.

Glyphosate Increases Brain TNFα

Findings of the study also revealed an increase in the following:

  • Brain TNFα in specific brain areas affected by neurodegenerative diseases such as Alzheimer’s.
  • Hippocampal TNFα levels
  • Cortical TNFα levels.

Collectively, the study suggested an increase in brain TNFα from glyphosate exposure.

Glyphosate Increases Peripheral Blood Plasma

The researchers analyzed blood plasma to determine the effect of glyphosate on the levels of TNFα in the periphery.

Findings of the experiment showed a significant dose-dependent increase in the levels of the following:

  • Brain TNFα
  • Brain homogenate
  • Hippocampal TNFα
  • Cortical TNFα. 

It also showed effects on the hippocampus, cortical homogenates, and cortex. There is a significant relationship between glyphosate and TNFα in the brain, especially in the brain’s specific regions.

Brain Glyphosate Levels Correlation with Brain TNFα Levels

Different linear correlation models revealed a positive correlation between the levels of the following:

  • Brain glyphosate and brain TNFα
  • Brain glyphosate and peripheral blood plasma
  • Urine and brain glyphosate
  • Urine glyphosate and peripheral blood plasma TNFα.

Exposure to Glyphosate Results in Transcriptomic Dysregulation

The study sets out to find the transcriptome change after glyphosate exposure. Analysis of cell-specific changes in gene expression revealed a positive enrichment of oligodendrocytes. It also saw the enrichment of oligodendrocytes in various biological processes, including central nervous system myelination.

Key Takeaway of the Recent Experiment and Neurodegenerative diseases

  • Glyphosate showed a dose-dependent increase in brain tissue, supporting previous study results.
  • Possible degradation of glyphosate in vivo models suggests small amounts of AMPA. However, further research is required.
  • Exposure to glyphosate in mice suggested heightened levels of TNFα in blood plasma.
  • Elevated levels of TNFα in brain homogenates.
  • High levels of TNFα in specific brain regions affected by Alzheimer’s disease.
  • Brain glyphosate correlates with brain TNFα levels
  • There is a positive correlation between brain glyphosate and blood plasma and brain and urine glyphosate.
  • Glyphosate leads to higher cytotoxicity and reduced cell viability.
  • Glyphosate alters gene expression.
  • Glyphosate induces human breast cancer cells growth through its estrogen receptors.
  • The doses used on mice are above the daily human exposure but a benchmark set by Environmental Protection Agency for experiments on rodents.

Dose dependent glyphosate accumulation infiltrating brain tissue in the human body is real. Brain tissue revealed glyphosate infiltrated the brain of test subjects, including mice. Chronic pesticide exposure in testing shows major health problems with glyphosate treated groups compared with the general population. So if you work around corn and soy crops you will likely have a higher, more significant dose dependent response.

Persistent exposure means farm workers in the Central Valley of California will have higher environmentally relevant concentrations and greater chance of contracting brain disorders over their lives. Additionally, like Agent Orange, the neurological disorders can lead to dysregulated gene expression and DNA damage/birth defects/disfigurement. Other disorders can include neurodegenerative diseases like alzheimer’s and and oligodendrocyte development.

Schedule a Free Consultation with Ehline Law Glyphosate exposure Injury Lawyers

Are you worried about differential expression analysis results after dosage regression? The recent study raises awareness of the detrimental effects and potential hazards of glyphosate exposure has on the masses of people who are still using glyphosate products.

If you’re suffering from health conditions and are using glyphosate-based herbicides / pesticides, there is a likelihood that the herbicide has something to do with your deteriorating health. Contact us at (213) 596-9642 for a free consultation with our legal experts, as you may qualify for compensation after glial cell development from pesticide use.

Neurological Health Citations:

  • Arizona State University and the Arizona-based Translational Genomics Research Institute.

  • 2019 Pandey A , Dhabade P , Kumarasamy A. 2019 . Inflammatory effects of subacute exposure of Roundup in rat liver and adipose tissue . Dose Response. 17: 1559 . [Crossref] , [Web of Science ®] , [Google Scholar].
  • J Environ Res Public Health. 2022 Apr 19;19(9):4966. doi: 10.3390/ijerph19094966. Int J Environ Res Public Health. 2022. PMID: 35564359 Free PMC article. See all similar articles References Alavanja MCR, Hoppin JA, Kamel F. Health effects of chronic pesticide exposure: cancer and neurotoxicity. Annu Rev Public Health. 2004;25:155–197. doi: 10.1146/annurev.publhealth.25.101802.123020. – DOI – PubMed Benbrook CM.
  • Ait Bali et al. 2017 Ait Bali Y , Ba-Mhamed S , Bennis M. 2017 . Behavioral and immunohistochemical study of the effects of subchronic and chronic exposure to glyphosate in mice . Front Behav Neurosci. 11: 146 . [Crossref] , [PubMed] , [Web of Science ®] , [Google Scholar].
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