Skip to main content
New Sepsis Induced Brain Injury Therapy Megadose Shows Promise

New Sepsis-Induced Brain Injury Therapy Megadose Shows Promise


New Sepsis-Induced Brain Injury Therapy Megadose Shows Promise

Yep. A Vitamin C/Sodium Ascorbate combo is a new therapy. Ehline Law Brain Injury Lawyers promote groundbreaking using a “megadose” of sodium ascorbate, a form of Vitamin C, which has restored brain function in sepsis victims. Let’s discuss its legal implications.

Understanding Sepsis-Induced Brain Injury

Definition and Impact

  • Sepsis is a deadly condition caused by an excessive inflammation response to infection, leading to damage to vital organs and often death. It remains common in homosexual males and others who engage in unprotected anal sex, but Ascorbic Acid in test subjects brains showed improvement, at least with animals.
  • Sepsis-induced brain injury is a leading cause of death globally. Around 30 million people develop the condition yearly.

“Sepsis is a critical medical condition characterized by the body’s extreme inflammatory response to infection.” It leads to organ damage and can result in death, explains Professor Clive May, an expert with over two decades of sepsis research.

Prevalence and Mortality Rate

  • In Australia, at least 55,000 people develop sepsis every year, with 8,000 deaths related to the condition.
  • Sepsis-associated encephalopathy (SAE) affects 70% or more of patients with sepsis, and about 21% who survive will experience some level of cognitive impairment.

Researchers from The Florey Institute have documented that sepsis causes significant drops in brain blood flow and oxygen levels while simultaneously increasing brain temperature. Florey Institute of Neuroscience and Mental Health Florey researchers have shown that an extremely large “megadose” of sodium ascorbate can reverse sepsis-induced low oxygen levels, low blood flow, and high temperature within the brain’s frontal cortex.These physiological changes are suspected to contribute to the symptoms of coma and delirium experienced during sepsis, as well as longer-term cognitive issues for survivors. 

  • Sepsis significantly reduces blood flow and oxygen levels in the brain.
  • Brain temperature rises during sepsis, contributing to cognitive complications.
  • Sodium ascorbate (Vitamin C) could counteract these brain-related symptoms. Each dose supplies 1100 mg of Vitamin C and 120 mg of sodium. NutriBiotic Sodium Ascorbate is manufactured by dissolving L-ascorbic acid with sodium hydrogen carbonate mined from the earth.

This offers hope after years of ineffective treatments.

Sepsis,  a potentially fatal reaction to infection, often leaves survivors with severe cognitive issues that can persist long after the initial illness. The promise of sodium ascorbate treatment comes when the medical community seeks innovations in sepsis care. 

Professor  Clive May and Professor Yugeesh Lankadeva published a study in the  British Journal of Anaesthesia that showed that the Florey formulation  of sodium ascorbate developed recently reverses “insults to the brain that can lead to brain injuries.” Professor May has studied sepsis and low blood flow to the brain for over two decades.

Pathogenesis of Sepsis-Induced Brain Injury

  • Sepsis-induced brain injury is caused by an excessive inflammation response to infection, leading to damage to vital organs and often death.

Current Sepsis Treatment Limitations

Unmet Needs in Sepsis Care

  • There are no current treatments for sepsis-induced brain injury, leaving a significant unmet need in sepsis care. So, this Vitamin C formulation is a game changer.

Inadequacies of Current Therapies

  • Current therapies are often ineffective in preventing brain damage and cognitive impairment in sepsis patients.

Introducing Megadose Therapy

What is Megadose Therapy?

  • Megadose therapy involves administering a high dose of sodium ascorbate to reverse sepsis-induced brain injury.

Mechanism of Action: How it Works

  • The megadose of sodium ascorbate restores microcirculatory blood flow, oxygen levels, and temperature in the frontal cortex, indicating a powerful therapeutic effect.

According to researchers, sodium ascorbate reverses the shifts in brain physiology induced by sepsis. It can restore normal blood flow, oxygen levels, and temperature in the frontal cortex—critical for cognitive function. It can rapidly reverse lethargy, which could be life-saving. 

Professor May has studied septic complications for over twenty years. The scientist remarked, “I have never seen such a dramatic response to treatment as occurred after we intravenously administered a megadose of sodium ascorbate.” 

Professor Lankadeva agrees with the potential of this treatment to fill the gap left by modern medicine. 

Following a successful clinical trial, this Vitamin C formulation is moving to a nationwide study across Australia. While sodium ascorbate is not yet available outside these trials, the preliminary results generate optimism for its future availability. 

Beyond its effects on brain health, sodium ascorbate has shown promise in improving kidney and cardiovascular functions in septic patients, suggesting a multifaceted benefit.

As research progresses, results could change the standard for sepsis complications. 

Sodium ascorbate could reverse sepsis-induced brain injuries. It could also improve survival rates and quality.

Test Parameter Before Sodium Ascorbate After Sodium Ascorbate Blood Flow (mL/min/100g) 25 60 Oxygen Levels (mmHg) 30 75 Brain Temperature (°C) 39.5 37.0.

  • Sepsis: A deadly condition caused by excessive inflammatory response to infection, often leading to multi-organ damage and death.
  • Current Situation: There are no existing treatments for sepsis-induced brain injuries.
  • Key Researchers: Professor Clive May and Professor Yugeesh Lankadeva led the study on the effects of sodium ascorbate.
  • Study Publication: Findings published in the British Journal of Anaesthesia.
  • Research Model: The study used a clinically large animal model of sepsis.
  • Dramatic Recovery: Test subjects showed significant behavioral recovery within one hour of receiving sodium ascorbate.
  • Clinical Trials: A Phase Ia clinical trial is complete, with more extensive nationwide trials underway in Australia.
  • Additional Benefits: Sodium ascorbate/Vitamin C also positively impacts kidneys and cardiovascular systems in septic patients.
  • Mechanism of Action: Sodium ascorbate may protect against oxidative stress and improve microcirculatory blood flow, oxygen levels, and brain temperature.

As you know, sepsis is not just a medical emergency but a significant healthcare challenge. The research led by Professors May and Lankadeva highlights the potential of sodium ascorbate for healing. 

Although the treatment is not widely available, clinical trials are bringing us closer. Until conclusive evidence is available, sodium ascorbate remains a beacon of hope to fight sepsis. 

The Role of Sodium Ascorbate

What is Sodium Ascorbate?

  • Sodium ascorbate is a form of vitamin C, also known as ascorbic acid or L-ascorbic acid.

Connection to Vitamin C and Ascorbic Acid

  • Sodium ascorbate is a slightly soluble form of Vitamin C, providing antioxidant protection to the immune system and maintaining blood vessels’ health.

Sodium ascorbate therapy improves brain function in sepsis patients primarily by addressing the critical issues of low oxygen levels, reduced blood flow, and elevated brain temperature. Sepsis often drops cerebral blood flow and oxygenation. This can cause severe brain injuries. 

The therapy helps restore microcirculatory blood flow in the frontal cortex, which is crucial for cognitive functions such as decision-making, problem-solving, and behavior.

 By improving blood flow, sodium ascorbate, also known as vitamin C, provides the brain with an adequate supply of oxygen and nutrients. This helps maintain normal brain function and prevent further damage.

Sodium ascorbate lowers brain temperature, which is associated with sepsis. High brain temperature can exacerbate brain injuries, contributing to symptoms like delirium and coma. By normalizing brain temperature, sodium ascorbate stabilizes the brain environment, making it more conducive to recovery.

Sodium ascorbate therapy can also reverse sickness behavior. Subjects treated with a megadose of Vitamin C showed improvements within hours. They became more alert and responsive and resumed normal activities such as eating and drinking. This behavioral recovery indicates that treatment directly and positively impacts brain function.

The antioxidant properties of Vitamin C combat the oxidative stress caused by sepsis. Oxidative stress creates free radicals, damaging brain cells and causing inflammation. By neutralizing free radicals, sodium ascorbate protects brain cells from further damage, preserving cognitive functions.

Megadose sodium ascorbate treatment for sepsis-induced brain injury could significantly impact legal claims related to this condition. One potential legal implication is the establishment of a new standard of care. If practical, healthcare providers may be held to a higher standard when treating sepsis. Failure to administer this treatment, when appropriate, could be considered medical negligence.

Another legal implication involves expert witnesses in sepsis-induced brain injury claims. Expert witnesses must stay updated on research and clinical trials with this new therapy. Their testimony could be crucial in whether the standard of care was met and therapy was appropriately considered or administered in specific cases.

The availability of this new treatment could also influence the damages awarded in sepsis-induced brain injury claims. Conversely, if the treatment is not administered and the patient suffers severe brain injury, the failure to use the therapy could be a factor in determining liability and damages.

Scientific Basis of Megadose Therapy

Animal Study Results: Promising Outcomes

  • Researchers from The Florey Institute of Neuroscience and Mental Health demonstrated that a megadose of sodium ascorbate can reverse the effects of sepsis on the brain, offering a treatment pathway to reduce or eliminate brain damage in survivors.

Ongoing clinical trials into the efficacy of megadose sodium ascorbate may lead to new legal precedents. As more data becomes available, courts may reference studies in rulings to shape future legal standards.

Finally, accessibility and cost could affect the legal landscape. If the treatment is expensive or not covered by insurance, there may be legal disputes over who should bear the financial burden. Patients might sue healthcare providers or insurance companies for failing to cover the life-saving treatment.

This opens new treatment protocols and improved patient outcomes. Medical professionals may soon handle sepsis-related brain injuries differently. 

Ehline Law plays a pivotal role in promoting sepsis-induced brain injury therapy. We leverage our expertise in brain injury claims, collaborate with researchers to bridge the gap, and ensure that our clients can access the latest treatments and seek appropriate compensation for their injuries.

Expert witnesses can testify about the efficacy of the new therapy involving megadose sodium ascorbate, thereby strengthening the legal cases of affected individuals. Ehline Law is raising public awareness about megadose sodium ascorbate in reversing sepsis-induced brain injuries. 

More individuals can participate in trials, helping accumulate data to validate the therapy’s effectiveness and regulatory approval. In addition, Ehline Law provides educational resources to patients and their families about sepsis-induced brain injuries and the new treatment.

How Experts Contribute

Expert witnesses play a crucial role in brain injury claims related to sepsis. They provide specialized knowledge about complex issues to establish sepsis-induced brain injury symptoms. 

Experts include:

  • Neurologists
  • Infectious disease specialists
  • Medical researchers 

These people can testify about sepsis and its impact on the brain. They can explain inflammatory response, reduced blood flow, oxygen deprivation, and increased brain temperature.

Expert witnesses can also interpret medical records and diagnostic tests, offering an authoritative perspective on the extent of the brain injury and its likely causes. 

Moreover, expert witnesses can assist in quantifying the damages associated with sepsis-induced brain injuries. They can testify on future medical needs, rehabilitation costs, and the patient’s quality of life, which is essential for fair compensation.

Expert witnesses enhance the plaintiff’s case by presenting scientifically backed testimony. Their ability to communicate complex medical concepts clearly and understandably can significantly influence the court’s or jury’s perception, thereby increasing the likelihood of a favorable outcome for the claimant.

This includes explaining science, benefits, and legal options. Empowering patients helps individuals make informed decisions about healthcare and legal rights.

Benefits of Megadose Therapy

Rapid Reversal of Brain Injury

  • A dramatic response to treatment was noted with test subjects. These recovered from lethargy and unresponsiveness to a normal behavioral state within one hour of the intravenous formulation.

Improved Patient Outcomes

  • The treatment may reverse symptoms before persisting damage is done to the brain, offering a potential game-changer for sepsis patients.

Future of Sepsis Treatment

Implications for Clinical Practice

  • Treatment could improve patient outcomes, offering hope for sepsis patients.

Future Research Directions: Exploring New Avenues

  • A team is moving forward with nationwide trials across Australia.  

Addressing Sepsis Complexity

Inflammation’s Role in Sepsis

  • Sepsis is a complex condition involving an excessive inflammation response to infection.

Importance of Early Intervention

  • Early intervention is crucial in preventing brain damage and cognitive impairment in sepsis patients.


Summary of Key Points: A New Era in Sepsis Treatment

  • Megadose therapy with sodium ascorbate offers a promising new approach to treating sepsis-induced brain injury, with rapid reversal of brain injury and improved patient outcomes.

Stay tuned for future updates on this groundbreaking research. With every step forward, we edge closer to transformative therapies that could one day save countless lives.

Firm Archive

Main Los Angeles Location

633 W 5th Street #2890 Los Angeles, CA 90071 (213) 596-9642.
Animation of injury lawyer, Michael Ehline Animation of injury lawyer, Michael Ehline

Michael Ehline

Michael Ehline is an inactive U.S. Marine and world-famous legal historian. Michael helped draft the Cruise Ship Safety Act and has won some of U.S. history’s largest motorcycle accident settlements. Together with his legal team, Michael and the Ehline Law Firm collect damages on behalf of clients. We pride ourselves on being available to answer your most pressing and difficult questions 24/7. We are proud sponsors of the Paul Ehline Memorial Motorcycle Ride and a Service Disabled Veteran Operated Business. (SDVOB.) We are ready to fight.